Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
271 Cefotaxime 1 g Injection J01DD01520P4002XX A Infections due to gram-negative bacteria ADULT: 1 g 12 hourly (up to 12 g/day in severe cases). CHILD: 50 - 180 mg/kg/day in 4 - 6 divided doses
272 Cefotaxime 500 mg Injection J01DD01520P4001XX A Infections due to gram-negative bacteria ADULT: 1 g 12 hourly (up to 12 g/day in severe cases). CHILD: 50 - 180 mg/kg/day in 4 - 6 divided doses
273 Ceftaroline Fosamil 600mg Powder for concentrate for solution for infusion J01D102000P4001XX A* Treatment of complicated skin and soft tissue infections (cSSTI) in adults Restriction: Restricted for only complicated SSTI in patients who are unable to tolerate or not responding to vancomycin. 600mg administered every 12 hours by intravenous infusion over 60 minutes for 5-14 days. Dose adjustment in renal impairment: - CrCl > 30 to ≤50 ml/min : 400mg (IV) every 12 hours (over 60 minutes) - CrCl ≥ 15 ≤ 30 ml/min: 300mg (IV) every 2 hoours (over 60 minutes) - CrCl < 30ml/min including hemodialysis*: 200mg (IV) every 12 hours (over 60 minutes) * Ceftaroline is hemodialyzable, thus should be administered after hemodialysis.
274 Ceftazidime 1 g Injection J01DD02520P4003XX A Severe gram negative bacterial infections ADULT: 1 g 8 hourly or 2 g 12 hourly. In severe infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 - 3 divided doses
275 Ceftazidime 2 g Injection J01DD02520P4004XX A Severe gram negative bacterial infections ADULT: 1 g 8 hourly or 2 g 12 hourly. In severe infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 - 3 divided doses
276 Ceftolozane 1000mg & Tazobactam 500mg Injection J01DI54-000-P40-01-001 A* For the treatment of patients 18 years or older with the following infections. i) Treatment of complicated Intra-abdominal Infections (cIAI), to be used in combination with metronidazole. ii) Treatment of complicated Urinary Tract Infections (cUTI) including Pyelonephritis Confirmed carbapenem-resistant Pseudomonas aeruginosa as an alternative to Polymyxins (Polymyxin sparing). 1.5g (ceftolozane 1g and tazobactam 0.5g) administered every 8 hours by intravenous infusion over 1 hour in patients 18 years or older with normal renal function or mild renal impairment. i) 1.5g every 8 hours for 4-14 days ii) 1.5g every 8 hours for 7 days
277 Ceftriaxone 0.25 g Injection J01DD04520P4001XX A/KK i) Gonorrhoea ii) Chancroid i) 250 mg by deep IM injection ii) single IM injection 250 mg only. For severe infection up to 100 mg/kg/day
278 Ceftriaxone 0.5 g Injection J01DD04520P4002XX A Infections caused by susceptible organisms ADULT: 1 - 2 g once daily. Severe infection: 4 g daily at 12 hour intervals. INFANT & CHILD, 3 weeks - 12 years: 20 - 80 mg/kg body weight daily. CHILD with body weight 50 kg or more: adult dose. NEONATE up to 2 weeks: 20 - 50 mg/kg body weight daily, not to exceed 50 mg/kg
279 Ceftriaxone 1g Injection J01DD04520P4003XX A Infections caused by susceptible organisms ADULT: 1 - 2 g once daily. Severe infection: 4 g daily at 12 hour intervals. INFANT & CHILD, 3 weeks - 12 years: 20 - 80 mg/kg body weight daily. CHILD with body weight 50 kg or more: adult dose. NEONATE up to 2 weeks: 20 - 50 mg/kg body weight daily, not to exceed 50 mg/kg
280 Cefuroxime Axetil 125 mg Tablet J01DC02233T1001XX A/KK Upper and lower respiratory tract, genito-urinary tract, skin & soft tissue and urinary tract infections (UTI) ADULT: 250 mg twice daily ;UTI: 125 mg twice daily. CHILD:30 mg/kg/day in 2 divided doses, up to 500 mg daily
281 Cefuroxime Axetil 125 mg/5 ml Suspension J01DC02233F2101XX A Infections caused by susceptible organisms 30 mg/kg/day in 2 divided doses, up to 500 mg daily.
282 Cefuroxime Axetil 250 mg Tablet J01DC02233T1002XX A/KK Upper and lower respiratory tract, genito-urinary tract, skin & soft tissue and urinary tract infections (UTI) ADULT: 250 mg twice daily ;UTI: 125 mg twice daily. CHILD:30 mg/kg/day in 2 divided doses, up to 500 mg daily
283 Cefuroxime Sodium 1.5 g Injection J01DC02520P4003XX A Infections caused by susceptible organisms, surgical prophylaxis ADULT: 750 mg every 6 - 8 hours as IM or IV. Severe infections: 1.5 g every 6 - 8 hours as IV. CHILD: 30 - 100 mg/kg/day in 3 - 4 divided doses or 2-3 divided doses in neonates. Surgical prophylaxis: 1.5 g IV
284 Cefuroxime Sodium 750 mg Injection J01DC02520P4002XX A Infections caused by susceptible organisms, surgical prophylaxis ADULT: 750 mg every 6 - 8 hours as IM or IV. Severe infections: 1.5 g every 6 - 8 hours as IV. CHILD: 30 - 100 mg/kg/day in 3 - 4 divided doses or 2-3 divided doses in neonates. Surgical prophylaxis: 1.5 g IV
285 Celecoxib 200 mg Capsule M01AH01000C1001XX A i) Osteoarthritis ii) Rheumatoid Arthritis iii) Acute pain iv) Ankylosing Spondylitis i) ADULTS: 200 mg once daily. May increase to 200 mg bid, if necessary. CHILD not recommended ii) 100mg twice daily, increased if necessary to 200 mg 2 times daily; CHILD not recommended iii) 400mg as a single dose on first day followed by 200mg once daily on subsequent days iv) Initial, 200 mg once daily or 100 mg twice daily; if no effect after 6 weeks, may increase to max. 400 mg daily in 1-2 divided doses. If no response following 2 weeks of treatment with 400 mg/day, consider discontinuation and alternative treatment
286 Celecoxib 400 mg Capsule M01AH01000C1002XX A* i) Osteoarthritis ii) Rheumatoid Arthritis iii) Acute pain iv) Ankylosing Spondylitis i) ADULTS: 200 mg once daily. CHILD not recommended ii) 100 mg twice daily, increased if necessary to 200 mg 2 times daily; CHILD not recommended iii) 400 mg as a single dose on first day followed by 200 mg once daily on subsequent days iv) Initial, 200 mg once daily or 100 mg twice daily; if no effect after 6 weeks, may increase to max. 400 mg daily in 1-2 divided doses. If no response following 2 weeks of treatment with 400 mg/day, consider discontinuation and alternative treatment
287 Cephalexin Monohydrate 125 mg/5 ml Syrup J01DB01010F2101XX B Respiratory tract infections, ear, nose and throat infections, urinary tract infections, obstetric and gynaecologic infections CHILD: 25 - 100 mg/kg/day every 6 hourly. Maximum: 4 g daily
288 Cephalexin Monohydrate 250 mg Capsule J01DB01010C1001XX B i) Respiratory tract infection, urinary tract infection ii) Complicated, recurrent or chronic infections, bronchitis iii) Pneumonia i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g 3 times daily or 4 times daily. Maximum: 6 g/day Child: 25-100 mg/kg daily in divided doses. Max: 4 g daily.
289 Cephalexin Monohydrate 250 mg Tablet J01DB01010T1001XX B i) Respiratory tract infection, urinary tract infection ii) Complicated, recurrent or chronic infections, bronchitis iii) Pneumonia i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g 3 times daily or 4 times daily. Maximum: 6 g/day Child: 25-100 mg/kg daily in divided doses. Max: 4 g daily.
290 Cephalexin Monohydrate 500 mg Capsule J01DB01010C1002XX B i) Respiratory tract infection, urinary tract infection ii) Complicated, recurrent or chronic infections, bronchitis iii) Pneumonia i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g 3 times daily or 4 times daily. Maximum: 6 g/day
291 Cephalexin Monohydrate 500 mg Tablet J01DB01010T1002XX B i) Respiratory tract infection, urinary tract infection ii) Complicated, recurrent or chronic infections, bronchitis iii) Pneumonia i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g 3 times daily or 4 times daily. Maximum: 6 g/day Child: 25-100 mg/kg daily in divided doses. Max: 4 g daily.
292 Cetirizine HCl 10 mg Tablet R06AE07110T1001XX B Urticaria, allergic dermatoses (insect bites, atopic eczema), perennial rhinitis, allergic rhinitis ADULT and CHILD over 6 years:10 mg daily or 5 mg twice daily. Child 2-6 years: 5 mg once daily or 2.5 mg twice daily
293 Cetrimide 1-2% Lotion. D08AJ04000L6001XX C+ As shampoo and cleansing agent Apply to affected area
294 Cetrorelix 0.25 mg Injection H01CC02122P4001XX A* Prevention of premature ovulation in patients undergoing a controlled ovarian stimulation, followed by oocyte pick-up and assisted reproductive techniques Given by SC 0.25 mg/day, given either in the morning beginning on the day 5 or 6 of ovarian stimulation or in the evening beginning on day 5, and continued until ovulation induction
295 Cetuximab 5 mg/ml Solution for Infusion L01XC06000P5002XX A* For neo-adjuvant treatment of KRAS wild type metastatic colorectal cancer with the aim of liver resection. To be prescribed in patients with the following conditions: i) The primary colorectal tumour has been resected or is potentially resected. ii)The metastatic disease is confined to the liver and is unresectable iii) Patient is fit enough to undergo surgery to resect the primary colorectal tumour and to undergo liver surgery if the metastases become resectable after treatment with cetuximab. - The treatment is limited to 16 weeks Administered once a week. The very first dose is 400mg cetuximab per m2 body surface area with a recommended infusion period of 120 minutes. All subsequent weekly doses are 250mg per m2 body surface area each with a recommended infusion period of 60 minutes. The maximum infusion rate must not exceed 10mg/min.
296 Charcoal, Activated 250 mg Tablet A07BA01000T1001XX C i) Diarrhoea and food poisoning ii) Reduce absorption of drugs, plant, inorganic poison and chemicals in poisoning cases i) ADULT 0.5-1 g given 3-4 times daily. CHILD half adult dose. ii) Need to be dissolved in liquid (slurry consistency). ADULT and CHILD over 12 years: initial 30-100 g or 1-2 g/kg; repeat initial dose as soon as possible or 20-50 g every 2-6 hours. CHILD over 1-12 years, 25-50 g or 1-2 g/kg; may repeat half the initial dose every 2-6 hour as needed. CHILD to 1 year of age, 1 g/kg; may repeat half the initial dose every 2-6 hours as needed. For maximum efficacy administer within 1 hour after ingestion of toxic compound
297 Charcoal, Activated 50 g Granules A07BA01000F1001XX A Emergency treatment of acute oral poisoning and drug overdose ADULT:Acute poisoning: 50 - 100g in suspension. Severe poisoning: 50 - 100g as an initial dose followed by 20g every 4 - 6 hours. CHILDREN: 1g/kg/dose
298 Chloral Hydrate 200 mg/5 ml Mixture N05CC01010L2101XX B Preoperative sedation ADULT : 0.5 - 1 g (max 2 g) with plenty of water at bedtime. CHILD : Neonate: 30-50 mg/kg; up to 100 mg/kg may be used with respiratory monitoring. 1 mth-12 yr: 30-50 mg/kg (max: 1 g); up to 100 mg/kg (max: 2 g) may be used; 12-18 yr: 1-2 g. Doses to be taken 45-60 minutes before procedure. May be given rectally if oral route is not available.
299 Chlorambucil 2 mg Tablet L01AA02000T1001XX A Low grade lymphoma, chronic lymphocytic leukaemia. Ovarian cancer General : Initial :0.1 -0.2 mg/kg body weight daily for 4 - 8 weeks maintanance : given either by reduced daily dosage or intermittent course of treatment. Chronic Lymphocytic Leukaemia: initial : 0.15mg/kg/day untill total leukocyte count has fallen to 10,000peruL, then resumed treatment untill 4 weeks after the end of the first course then continued at a dosage 0.1mg/kg/day.
300 Chloramphenicol 0.5% Eye Drops S01AA01000D2001XX C Broad spectrum antibiotic in superficial eye infections Instill 1 drop of a 0.5% solution every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing

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