Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Dosage
241 Calcium Gluconate 10% Injection A12AA03000P3001XX B i)Acute hypocalcaemia ii)Hypocalcaemic tetany iii)Cardiac resuscitation i) 1-2 g (2.25-4.5 mmol). CHILD 50 mg/kg ii) ADULT 1g (2.2 mmol) by slow IV injection followed by continuous infusion of 4 g (8.8 mmol) daily iii) IV or intracardiac injection, 10 ml
242 Calcium Lactate 300 mg Tablet A12AA05125T1001XX C For prophylaxis of calcium deficiency and treatment of chronic hypocalcaemia ADULT 1-5 g daily in divided doses
243 Calcium Polystyrene Sulphonate Powder V03AE01999F2101XX A Hyperkalemia resulting from acute or chronic renal failure 15 - 30g daily in 2-3 divided doses. Each dose should be suspended in 30 - 50ml of water and administered orally
244 Calfactant 35mg/ml intratracheal suspension R07AA02000L9104XXX A* For the prevention of Respiratory Distress Syndrome (RDS) in premature infants at high risk for RDS and for the treatment (“rescue”) of premature infants who develop RDS. Prophylaxis: Indicated for premature infants <29 weeks of gestational age at significant risk for RDS. Should be administered as soon as possible, preferably within 30 minutes after birth. Treatment: Indicated for infants ≤72 hours of age with RDS (confirmed by clinical and radiologic findings) and requiring endotracheal intubation. 3mL/kg body weight at birth to be administered every 12 hours for total up to 3 doses. Should only be administered intratracheally though an endotracheal tube. The dose is drawn into a syringe from the single-use vial using a 20-gauge or larger needle with care taken to avoid excessive foaming. Administration is made by instillation of the calfactant suspension into the endotracheal tube.
245 Capecitabine 150 mg Tablet L01BC06000T1002XX A* 1) Metastatic breast cancer; 2) Treatment of colorectal cancer in adjuvant and metastatic setting; 3) advanced oesophagogastric cancer in combination with a platinum-based regimen. i) & ii) 1250 mg/m2 twice daily (morning and evening) for 2 weeks, every 21 days. iii) Recommended for a total of 24 weeks (8 cycles of 2 weeks of drug administration and 1 week rest period. Iv) In combination with a platinum on day 1, give capecitabine 1250 mg/m2 twice daily for 14 days. Repeated every 3 weeks for 8 cycles or optimum number of cycles
246 Capecitabine 500 mg Tablet L01BC06000T1001XX A* 1) Metastatic breast cancer; 2) Treatment of colorectal cancer in adjuvant and metastatic setting; 3) advanced oesophagogastric cancer in combination with a platinum-based regimen. i) & ii) 1250 mg/m2 twice daily (morning and evening) for 2 weeks, every 21 days iii) Recommended for a total of 24 weeks (8 cycles of 2 weeks of drug administration and 1 week rest period iv) In combination with a platinum on day 1, give capecitabine 1250 mg/m2 twice daily for 14 days. Repeated every 3 weeks for 8 cycles or optimum number of cycles
247 Captopril 25 mg Tablet C09AA01000T1002XX B i) Hypertension ii) Congestive heart failure iii) Post-myocardial infarction iv) Diabetic nephropathy i) Initially 12.5 mg twice daily. Maintenance: 25-50 mg 2 - 3 times daily, may be increased to maximum 450 mg/day in divided doses ii) Initially 6.25 - 12.5 mg 3 times daily, increase after several days to 25 - 50 mg 3 times daily iii) Start 3 days after MI Initially 6.25 mg daily, gradually increased to 37.5 mg daily in divided doses. May increase after several week to 150 mg/day in divided doses if needed and tolerated iv)75 - 100 mg daily in divided dose.
248 Carbachol 0.01% Intraocular Solution S01EB02100D2001XX A For intraocular use for miosis during surgery Instill no more than 0.5 ml gently into the anterior chamber
249 Carbamazepine 100 mg/5 ml (2% w/v) Syrup N03AF01000L9001XX A Epilepsy ADULT: Initially, 100-200 mg once or twice daily gradually increased by increments of 100-200 mg every 2 week. Maintenance: 0.8-1.2 g daily in divided doses. CHILD: 10-15 years: 0.6-1 g daily; 5-10 years: 400-600 mg daily; 1-5 years: 200-400 mg daily; less than or equal to 1 year: 100-200 mg daily. Alternatively, 10-20 mg/kg body weight daily in divided doses. Max: Adult: 1.6 g daily
250 Carbamazepine 200 mg CR Tablet N03AF01000T5001XX A Epilepsy ADULT: Initial, 200 mg twice daily for the first week, may increase dosage by 200 mg/day at weekly intervals until optimal response is obtained. Maximum 1.6 g/day. CHILD: usual maximum dosage 1000 mg/day in children 12-15 years of age, 1200 mg/day in patients above 15 years of age
251 Carbamazepine 200 mg Tablet N03AF01000T1001XX B i) Epilepsy ii) Trigeminal neuralgia i) ADULT: 100 - 200 mg 1 - 3 times daily increased gradually to usual dose of 0.8 - 1.2 g daily in divided doses. CHILD: Up to 1 year: 100 - 200 mg daily; 1 - 5 yrs: 200 - 400 mg daily; 5 - 10 years: 400 - 600 mg daily; 10 - 15 years: 0.6 - 1 g daily ii) The initial dosage of 200 to 400mg should be slowly raised daily until freedom from pain is achieved (normally at 200mg 3 to 4 times daily). The dosage should then be gradually reduced to the lowest possible maintenance level. In elderly patients, an initial dose of 100mg twice daily is recommended.
252 Carbamazepine 400 mg CR Tablet N03AF01000T5002XX A Epilepsy ADULT: Initial, 200 mg twice daily for the first week, may increase dosage by 200 mg/day at weekly intervals until optimal response is obtained. Maximum 1.6 g/day. CHILD: usual maximum dosage 1000 mg/day in children 12-15 years of age, 1200 mg/day in patients above 15 years of age
253 Carbamide (Urea) 10 % Cream D02AE01000G1001XX B Contact irritant dermatitis, infantile eczemas, acute and chronic allergic eczemas, icthyosis, hyperkeratotic Apply sparingly and rub into affected area 2 - 3 times daily and when required after cleansing skin
254 Carbetocin 100 mcg/ ml Injection H01BB03000P2001XX A* Prevention of uterine atony and postpartum hemorrhage following elective cesarean section under epidural or spinal anaesthesia A single IV dose of 100mcg (1ml) is adminitered by bolus injection, slowly over 1minute, only when delivery of the infant has been completed by caesarean section under epidural or spinal anaesthesia, before or after delivery of the placenta.
255 Carbimazole 5 mg Tablet H03BB01000T1001XX B Hyperthyroidism ADULT: Initially, 10-60mg daily in divided doses given 8 hourly. Maintenance: 5 to 20mg daily. CHILDREN > 6 years: Initially 15mg daily in divided doses. CHILDREN 1-6 years: Initially 7.5mg daily in divided doses
256 Carboplatin 150 mg Injection L01XA02000P4001XX A* 1) Solid tumours; 2) Salvage therapy for lymphoma 360 - 400 mg/m2 BSA, by IV infusion over 15 mins to 1 hour on Day 1 every 4 weeks. Alternatively, prescription may be based on Area Under Curve (AUC) calculations. CHILD: 500-600 mg/m2 over 1 hour once every 3 weeks. Salvage regimes in lymphomas - refer to specific protocols. Starting dose in renal impairment, please refer to product insert.
257 Carboplatin 450 mg Injection L01XA02000P4002XX A* 1) Solid tumours; 2) Salvage therapy for lymphoma 360 - 400 mg/m2 BSA, by IV infusion over 15 mins to 1 hour on Day 1 every 4 weeks. Alternatively, prescription may be based on Area Under Curve (AUC) calculations. CHILD: 500-600 mg/m2 over 1 hour once every 3 weeks. Salvage regimes in lymphomas - refer to specific protocols. Starting dose in renal impairment, please refer to product insert.
258 Carboprost Tromethamine 250 mcg Injection G02AD04999P3001XX A* Postpartum haemorrhage refractory to oxytocin Initially 250 mcg deep IM inj. The dose may be repeated at intervals of 15-90 min if necessary. Max total dose: 2 mg.
259 Cardioplegia solution containing Potassium Chloride, Magnesium chloride & Procaine HCl Injection B05XA16934P3001XX A* For myocardial preservation(prevent myocardial damage) during cardiac surgery Dilute 20 ml to 1 L of Ringer solution (cooled to 2-8 ∞C prior to use). Initial rapid instillation into aortic root at 300 ml/m≤ body surface area/min for 3 minutes. Should myocardial activity persist or recur instill at 300ml/m≤ body surface area/min for 2 minutes
260 Carvedilol 25 mg Tablet C07AG02000T1002XX A/KK Treatment of stable moderate to severe congestive cardiac failure in addition to ACEI's and diuretics 3.125 mg twice daily for 2 weeks, then 6.25 mg twice daily for 2 weeks, then 12.5 mg twice daily for 2 weeks then 25 mg twice daily (titrated up to the highest tolerated level). Max: <85 kg: 25 mg bid; >85 kg: 50 mg bid.
261 Carvedilol 6.25 mg Tablet C07AG02000T1001XX A/KK Treatment of stable moderate to severe congestive cardiac failure in addition to ACEI's and diuretics 3.125 mg twice daily for 2 weeks, then 6.25 mg twice daily for 2 weeks, then 12.5 mg twice daily for 2 weeks then 25 mg twice daily (titrated up to the highest tolerated level). Max: <85 kg: 25 mg bid; >85 kg: 50 mg bid.
262 Caspofungin Acetate 50 mg Injection J02AX04122P4001XX A* i) Confirmed systemic fungal infection in patients who are refractory or intolerant to other fungal therapies. ii) For pediatric patient (12 month and older) for the following indications : a) Empirical therapy for presumed fungal infections in febrile, neutropenic patients b) Treatment of invasive candidiasis, including candidemia and the following Candida infections ; intra-abdominal abscesses, peritonitis and pleural space infections c) Treatment of esophageal candidiasis d) Treatment of invasive Aspergillosis in patients who are refractory to or intolerant of others therapy (eg : Amphotericin B) i) Invasive aspergillosis & invasive candidiasis: ADULT: Initially, 70 mg infused over 1 hour followed by subsequent doses of 50 mg/day. Oesophageal candidiasis: ADULT: 50 mg by slow IV infusion over approximately 1 hour ii) For all indications, a loading dose of 70mg/m2 on D1 followed by maintenance dose of 50mg/m2 od.
263 Caspofungin Acetate 70 mg Injection J02AX04122P4002XX A* i) Confirmed systemic fungal infection in patients who are refractory or intolerant to other fungal therapies. ii) For pediatric patient (12 month and older) for the following indications : a) Empirical therapy for presumed fungal infections in febrile, neutropenic patients b) Treatment of invasive candidiasis, including candidemia and the following Candida infections ; intra-abdominal abscesses, peritonitis and pleural space infections c) Treatment of esophageal candidiasis d) Treatment of invasive Aspergillosis in patients who are refractory to or intolerant of others therapy (eg : Amphotericin B) i) Invasive aspergillosis & invasive candidiasis: ADULT: Initially, 70 mg infused over 1 hour followed by subsequent doses of 50 mg/day. Oesophageal candidiasis: ADULT: 50 mg by slow IV infusion over approximately 1 hour daily ii) Child (12months to 17 years) : For all indication) A single 70mg/m2 loading dose (not to exceed an actual dose of 70mg) by slow IV infusion over 1hour; followed by 50mg/m2 (not to exceed an actual dose of 70mg)
264 Cefaclor 125 mg/5 ml Suspension J01DC04000F2101XX A Infections caused by susceptible organisms including Staphylococcus aureus and H. influenzae, treatment of sinusitis and infections involving the respiratory tract, skin and skin structure, bone and joint, and urinary tract CHILD:>1 mth: 20 mg/kg daily in 3 divided doses, increased to 40 mg/kg daily if necessary, <1 yr: 62.5 mg tid, 1-5 yr: 125 mg tid, >5 yr: 250 mg tid. Maximum: 1 g daily
265 Cefaclor 375 mg MR Tablet J01DC04010T5001XX A i) Adult pharyngitis, tonsillitis, skin& soft tissue infections ii) Bronchitis iii) Pneumonia iv) Lower UTI i) 375 mg twice daily ii) 375 mg or 500 mg twice daily iii) 750mg twice daily iv) 375mg twice daily or 500 mg once daily
266 Cefaclor 500 mg Capsule J01DC04000C1002XX A Infections caused by susceptible organisms including Staphylococcus aureus and H. influenzae, treatment of sinusitis and infections involving the respiratory tract, skin and skin structure, bone and joint, and urinary tract ADULT: 250 mg 3 times daily for 10 days. For severe infections, double the dosage. Maximum: 4 g daily. CHILD:>1 mth: 20 mg/kg daily in 3 divided doses, increased to 40 mg/kg daily if necessary, <1 yr: 62.5 mg tid, 1-5 yr: 125 mg tid, >5 yr: 250 mg tid . Maximum: 1 g daily
267 Cefazolin Sodium 1 g Injection J01DB04520P3001XX A Infection caused by cefazolin-sensitive microorganism, infection of the respiratory tract, urogenital tract, skin and soft tissue, bile duct, bones and joint, endocarditis, systemic septic infection, peri-operative/ surgical prophylaxis ADULT: Uncomplicated infections: 500 - 1000 mg 2 - 3 times daily. Moderately severe and severe infections: 500 - 1000 mg 3 - 4 times daily. Severe life-threatening infections: 1 - 1.5 g 4 times daily. Rarely, dose up to 12 g daily. CHILDREN >1 month: 25-50mg/kg/day in 3-4 divided dose
268 Cefepime 1 g Injection J01DE01110P4002XX A* Febrile neutropenia, septicaemia, lower respiratory tract infection, urinary tract infection, skin and skin structure infections, gynaecologic and intra-abdominal infections ADULT: 1 - 2 g twice daily for most infections. For severe infections including febrile neutropenia: 2 g 3 times daily. CHILD:2 mth - 16 yr: ≤40 kg: 50 mg/kg every 8-12 hr for 7-10 days
269 Cefepime 500 mg Injection J01DE01110P4001XX A* Febrile neutropenia, septicaemia, lower respiratory tract infection, urinary tract infection, skin and skin structure infections, gynaecologic and intra-abdominal infections ADULT: 1 - 2 g twice daily for most infections. For severe infections including febrile neutropenia: 2 g 3 times daily. CHILD: 2 mth - 16 yr: ≤40 kg: 50 mg/kg every 8-12 hr for 7-10 days
270 Cefoperazone Sodium 1 g Injection J01DD12520P4002XX A Infections due to gram-negative bacteria ADULT: 1 - 2 g twice daily IM or IV. By IV, adult dose may be doubled. Maximum: 16 g daily in divided doses. CHILD & INFANT: 50 - 200 mg/kg/day in 2 - 4 divided doses. NEONATE less than 8 days: 50 - 200 mg/kg/day 12 hourly

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