Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Dosage
1531 Temozolomide 100 mg Capsule L01AX03000C1003XX A* In patients with glioblastoma multiforme who fulfill all the following criteria: i. Total /near total resection ii. ECOG/WHO performance status 0-2 iii. Age less than 60 years Concomitant phase : 75mg/m2 daily with radiotherapy for 42 days, followed by 6 cycle of adjuvant treatment. Adjuvant phase: Additional 6 cycles of adjuvant phase. Cycle 1- 150mg/m2 once daily for 5 days followed by 23 days without treatment. Cycle 2-6 : 200mg/m2 once daily for 5 days per 28-day cycle
1532 Temozolomide 20 mg Capsule L01AX03000C1001XX A* In patients with glioblastoma multiforme who fulfill all the following criteria : i. total /near total resection ii. ECOG/WHO performance status 0-2 iii. Age less than 60 years Concomitant phase : 75mg/m2 daily with radiotherapy for 42 days, followed by 6 cycle of adjuvant treatment. Adjuvant phase: Additional 6 cycles of adjuvant phase. Cycle 1- 150mg/m2 once daily for 5 days followed by 23 days without treatment. Cycle 2-6 : 200mg/m2 once daily for 5 days per 28-day cycle
1533 Tenecteplase 10,000 unit (50 mg) Injection B01AD11000P4001XX A* Acute myocardial reinfarction where streptokinase is contraindicated due to previous streptokinase induced antibodies. [Indicated when antibodies was given more than 5 days and less than 12 months] Less than 60 kg: 30 mg, 60 - 69 kg: 35 mg, 70 - 79 kg: 40 mg; 80 -90 kg: 45 mg, 90 kg or above: 50 mg. Administer single IV bolus over 5-10 seconds
1534 Tenofovir Disoproxil Fumarate 300 mg & Emtricitabine 200 mg Tablet J05AR03964T1001XX A/KK Treatment of HIV-1 infection in adults in combination with other antiretroviral agents (such as non-nucleoside reverse transcriptase inhibitors or protease inhibitors). 1 tablet once daily.
1535 Tenofovir Disoproxil Fumarate 300 mg Tablet J05AF07138T1001XX A* i)Treatment of HIV-1 infected adults in combination with other antiretroviral agents. ii)Use as first line monotherapy for chronic hepatitis B or as a rescue therapy for patients with drug resistance hepatitis B virus (according to resistant profile or treatment guidelines). 300mg once daily. Renal Dose Adjustment: 300mg every 48hours (30-49ml/min); 300mg every 72hours (10-29ml/min); 300mg every 7 days after dialysis (Hemodialysis)
1536 Terazosin HCl 1 mg Tablet G04CA03110T1001XX A/KK Only for treatment of Benign Prostatic Hyperplasia. Not to be used for treatment of hypertension Initially 1 mg at night, increased in a stepwise fashion to 2 mg, 5 mg or 10 mg once daily
1537 Terazosin HCl 2 mg Tablet G04CA03110T1002XX A/KK i) Treatment of Benign Prostatic Hyperplasia. ii)Hypertension i)Initially 1 mg at night, increased in a stepwise fashion to 2 mg, 5 mg or 10 mg once daily. ii)Initial: 1mg once daily at bedtime, Maintenance: 1-5mg once (morning or evening) or twice daily. Max: 20-40mg/day
1538 Terazosin HCl 5 mg Tablet G04CA03110T1003XX A/KK i) Treatment of Benign Prostatic Hyperplasia. ii)Hypertension i) Initially 1 mg at night, increased in a stepwise fashion to 2 mg, 5 mg or 10 mg once daily. ii) Initial: 1mg once daily at bedtime, Maintenance: 1-5mg once (morning or evening) or twice daily. Max: 20-40mg/day
1539 Terbinafine 1% gel D01AE15110G3001XXX A/KK Skin infections caused by dermatophytes, mould and candida. Prescribing restriction: Second line treatment Apply topically twice daily for 1 week (interdigital); apply topically twice (plantar) daily for 2 weeks. Children must be aged above 2 years old.
1540 Terbinafine HCl 250 mg Tablet D01BA02110T1001XX A/KK Fungal infections especially onchomycosis caused by dermatophytes 250 mg once daily for 6 weeks for fingernails: 12 weeks for toenails
1541 Terbutaline Sulphate 0.5 mg/ml Injection R03CC03183P3001XX B Bronchial asthma, chronic bronchitis, emphysema and other lung diseases where broncoconstriction is a complicating factor SC, IM or slow IV : 250-500 mcg up to 4 times daily. CHILD 2 - 15 years 10mcg/kg to a maximum of 300 mcg. Continuous IV infusion, as a solution containing 3 - 5 mcg/ml, 1.5 - 5 mcg/minute for 8 - 10 hours; reduce dose for children
1542 Terbutaline Sulphate 10 mg/ml Nebulizer Solution R03AC03183A3001XX B Asthma and other conditions associated with reversible airways obstruction ADULT : 5 - 10 mg 2 -4 times daily, additional doses may be necessary in severe acute asthma. CHILD up to 3 years : 2 mg, 3 - 6 years : 3 mg, 6 - 8 years : 4 mg, over 8 years : 5 mg 2 - 4 times daily
1543 Teriflunomide 14 mg tablet L04AA31-000-T32-01-XXX A* Treatment of adult patients with relapsing remitting multiple sclerosis (MS) 14mg once daily.
1544 Terlipressin 1mg Injection H01BA04000P4001XX A* Acute oesophageal variceal bleeding 2 mg IV bolus over 1 minute. Maintenance: 1 - 2 mg IV bolus 4 - 6 hourly until bleeding is controlled, up to 24 - 36 hours. The maximum daily dosage is 120-150 mcg/kg body weight.
1545 Testosterone 250 mg/ml Injection G03BA03000P3001XX A* Only for treatment of male infertility, protein deficiency during convalescence after surgery and wasting disorder. In women, supplementary therapy of progressive mammary carcinoma By IM only. Hypogonadism 250 mg every 2-3 weeks. To maintain an adequate androgenic effect 250 mg every 3-6 weeks. Potency disorders 250 mg every 4 weeks. Male climateric disorders: 250 mg every 3-4 weeks. Repeated 6-8 weeks courses at 2-3 months interval
1546 Tetanus Toxoid Injection J07AM01000P3001XX C+ Immunization against tetanus infection 2 doses of 0.5 mL IM at an interval of 4-8 wk, followed by the 3rd dose 6-12 mth later. Booster: 0.5 mL IM every 10 yr.
1547 Tetracycline HCl 250 mg Capsule J01AA07110C1001XX B Infections caused by susceptible pathogens "Adult: 250-500 mg 6 hrly. Max: 4 g/day. Child: ≥12 yr Max: 2 g daily"
1548 Tetracycline HCl 250 mg Tablet J01AA07110T1001XX B Infections caused by susceptible pathogens "Adult: 250-500 mg 6 hrly. Max: 4 g/day. Child: ≥12 yr Max: 2 g daily"
1549 Thalidomide 50 mg Capsule L04AX02000C1001XX A* First line induction therapy in newly diagnosed multiple myeloma, salvage therapy in relapsed multiple myeloma and maintenance therapy in multiple myeloma (contraindicated for pregnant women; pregnancy test for females in reproductive age group before starting treatment should be done). 50 mg to 200 mg daily
1550 Thallous Chloride (Thallium-201) Injection V09GX01100P3001XX A* Used in myocardial perfusion scintigraphy, acute myocardial infarction and post-surgical assessment of coronary artery bypass graft patency, muscle perfusion scintigraphy, visualisation of brain and thyroid tumours and metastases As IV infusion
1551 Theophylline 125 mg Tablet R03DA04000T1001XX B Reversible airways obstruction, acute severe asthma ADULT: 125 mg 3 - 4 times daily after food, increased to 250 mg if required. CHILD: 1 - 15 years : 5 mg/kg/dose (up to 600 mg/ day) every 3 - 4 times daily
1552 Theophylline 250 mg Long Acting Tablet R03DA04000T5001XX B Reversible airways obstruction and acute severe asthma ADULT: 250 mg 2 times daily. CHILD under 12 years : Up to 10 mg/kg body weight 2 times daily
1553 Theophylline 80 mg/15 ml Syrup R03DA04000L9001XX B Reversible airways obstruction and acute severe asthma ADULT : 125 mg 3 - 4 times daily after food, increased to 250 mg if required. CHILD 1 - 15 years : 5 mg/kg/dose (up to 600 mg/day) every 3 - 4 times per day
1554 Thiamine HCl 100 mg/ml Injection A11DA01110P3001XX B i) For the prevention or treatment of Vitamin B1 deficiency syndromes including beri-beri and peripheral neuritis associated with pellagra ii) Wernicke-Korsakoff Syndrome i) Mild to chronic deficiency: 10-25 mg daily. Severe deficiency: 200- 300 mg daily ii) 500 mg every 8 hours for 2 days, followed by 100 mg 2 times daily until patient can take oral dose
1555 Thiamine Mononitrate 10 mg Tablet A11DA01221T1002XX C For the prevention or treatment of Vitamin B1 deficiency syndromes including beri-beri and peripheral neuritis associated with pellagra i) Mild to chronic deficiency: 10-25 mg daily ii) Severe deficiency: 200- 300 mg daily
1556 Thiamine Mononitrate 3 mg Tablet A11DA01221T1001XX C For the prevention or treatment of Vitamin B1 deficiency syndromes including beri-beri and peripheral neuritis associated with pellagra i) Mild to chronic deficiency: 10-25 mg daily ii) Severe deficiency: 200 - 300 mg daily
1557 Thioguanine 40 mg Tablet L01BB03000T1001XX A For acute leukaemia and chronic granulocytic leukaemia Refer to specific protocols. Usually 100 mg/m2 for 5 - 7 days (acute myeloid leukaemia) or up to 2 weeks (chronic myeloid leukaemia for accelerated/ advanced disease). CHILD: 40 - 60 g/m2 daily according to protocol
1558 Thiopental Sodium 500 mg Injection N05CA19520P3001XX B i) General anaesthesia, induction ii) Anticonvulsant for cases resistant to conventional anticonvulsants in the ICU i) ADULT : For induction 200 - 400 mg. For repeat injection 3 - 5 mg/kg over 10 - 15 seconds until desired depth of anaesthesia is obtained. Not FDA approved for use in pediatric patients ii) 75 - 125 mg IV single dose; for local-anaesthetic induced convulsion: 125 - 250 mg IV over 10 minutes
1559 Thymol Compound Gargle A01AD11985M2001XX C For sore throat and minor mouth inflammation To be gargled 3-4 times daily
1560 Thyrotropin alfa 0.9mg/ml Injection H01AB01000P3002XX A* Thyrogen (thyrotropin alfa) is indicated for use as an adjunctive treatment for radioiodine ablation of thyroid tissue remnants in patients who have undergone a near-total or total thyroidectomy for well-differentiated thyroid cancer and who do not have evidence of distant metastatic thyroid cancer. A two-injection regimen is recommended for thyrotropin administration.The two-injection regimen is thyrotropin 0.9 mg intramuscularly (IM), followed by a second 0.9 mg IM injection 24 hours later. After reconstitution with 1.2 mL Sterile Water for Injection, 1.0 mL solution (0.9 mg thyrotropin alfa) is administered by intramuscular injection to the buttock. For radioiodine imaging or treatment, radioiodine administration should be given 24 hours following the final Thyrogen injection. Diagnostic scanning should be performed 48 hours after radioiodine administration, whereas post-therapy scanning may be delayed additional days to allow background activity to decline.

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