Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
1531 Ticagrelor 90 mg Tablet B01AC24-000-T10-01-XXX A* Co-administration with aspirin, for the prevention of atherothrombotic events: a) Second line treatment for patients readmitted to hospital with recurrent atherothrombotic event failing treatment with clopidogrel. b) STEMI patients going for invasive PCI c) NSTEMI/UA patients with intermediate to high risk TIMI score d) Other complicated ACS cases treated either medically or invasively via PCI or CABG (risk of Stent thrombosis, 3VD etc.) Initially, 180mg as single dose followed by 90mg bd with maintenance dose of ASA 75-150 mg daily.
1532 Ticlopidine HCl 250 mg Tablet B01AC05110T1001XX A/KK i) Prevention of thrombotic stroke for patients who are sensitive /intolerant to Acetysalicylic Acid ii) Maintenance of coronary bypass surgery or angioplasty iii) Maintenance of patency of access in patients on chronic haemodialysis 250 mg twice daily taken with food
1533 Timolol 0.5% Eye Drops S01ED01-253-D20-02-XX A Elevated intraocular pressure, chronic open angle glaucoma One drop in the affected eye(s) twice daily or as directed by physician
1534 Timolol 0.5% Ophthalmic Gel Forming Solution S01ED01-253-D20-02-XXX A Elevated intraocular pressure, chronic open angle glaucoma One drop in the affected eye(s) once a day
1535 Tinidazole 500 mg Tablet P01AB02000T1001XX B i) Amoebiasis ii) Urogenital trichomoniasis and giardiasis i) ADULT : 2 g as a single dose for 2 - 3 days. CHILD 3 years and older : 50 mg/kg daily for 3 days ii) ADULT : 2 g as a single dose (repeated once if necessary). Sexual partners should be treated concomitantly with the same dose. CHILD 6 years and older : single dose of 1 gram
1536 Tioconazole 100 mg Vaginal Tablet G01AF08000S1001XX A Vulvovaginal candidiasis Adult & Child > 12yr: Insert nightly on retiring for 3-6 or 14 days
1537 Tiotropium 2.5mcg and Olodaterol 2.5mcg per actuation, inhalation R03AL06-989-A10-01-XXX A/KK As a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD). Patients without inhaler coordination problem (Only applies to Primary Care settings) 2 puffs once daily, at the same time of the day.
1538 Tiotropium 2.5mcg/puff solution for inhalation R03BB04-320-A30-01-XXX A/KK i) Maintenance bronchodilator treatment to relieve symptoms of patients with chronic obstructive pulmonary disease (COPD). ii) As add-on maintenance bronchodilator treatment in adult patients (18 years and older) with asthma who are currently treated with the maintenance combination of inhaled corticosteroids (≥800µg budesonide/day or equivalent) and long-acting β2-agonist and who experienced one or more severe exacerbations in the previous year. For indication (i): The diagnosis of COPD should be confirmed by spirometry. 5 mcg (2 puff) once daily, at the same time of the day
1539 Tirofiban HCl 0.25 mg/ml Injection B01AC17110P9901XX A* Unstable angina or non-ST segment elevation myocardial infarction with the following: elevated cardiac markers, refractory chest pain, ST-segment changes and thrombolysis in myocardial infarction (TIMI) risk score 4 By IV infusion, 0.4 mcg/kg/min for 30 minutes, then 0.1 mcg/kg/min for at least 48 hours, maximum 108 hours
1540 Tocilizumab 162mg/0.9ml solution for injection in prefilled syringe (for subcutaneous injection) L04AC07000P3003XX A* Indicated for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients: i) with inadequate respond or intolerance to conventional disease- modifying antirheumatic drugs (DMARDS) ii) who has failed antitumour necrosis factors (antiTNFs) iii) where TNF is contraindicated (patients with history of pulmonary tuberculosis [PTB]) It also can be used as monotherapy or with combination with methotrexate (MTX) and/ or other DMARDS. Adult patients: 162mg given once every week as a subcutaneous injection.
1541 Tocilizumab 20 mg/ml Injection L04AC07-000-P30-01-001 A* Indicated for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients: i) with inadequate respond or intolerance to conventional disease- modifying antirheumatic drugs (DMARDS) ii) who has failed antitumour necrosis factors (antiTNFs) iii) where TNF is contraindicated (patients with history of pulmonary tuberculosis [PTB]) It also can be used as monotherapy or with combination with methotrexate (MTX) and/ or other DMARDS. Recommended dose for rheumatoid arthritis of tocilizumab for adult patients is 8mg/kg given once every 4 weeks as a single-drip IV infusion over 1 hour. It should be diluted to 100 ml by a healthcare professional with sterile 0.9% w/v sodium chloride solution over 1 hour. For patients whose body weight is more than 100kg, doses exceeding 800mg per infusion are not recommended
1542 Tofacitinib citrate 5mg film coated tablet L04AA29136T3201XX A* Indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. It may be used as monotherapy or in combination with methotrexate or other non-biologic disease-modifying anti-rheumatic drugs (DMARDs). One tablet twice daily
1543 Tolterodine Tartrate ER 4 mg Capsule G04BD07123C2002XX A* Treatment of overactive bladder with symptoms of urinary, frequency or urge incontinence 4 mg once daily. May decrease to 2 mg once daily depending on response and tolerability
1544 Topiramate 100 mg Tablet N03AX11-000-T10-03-XXX A* As adjunctive therapy for adults and children (2 years and above) with: i) partial onset seizures and generalized tonic-clonic seizures ii) seizures associated with Lennox Gastaut syndrome. ADULT: Usual daily dose: 200-400 mg/day. CHILD: Daily doses up to 30mg/kg/day Dosing is according to product insert.
1545 Topiramate 25 mg Capsule Sprinkle N03AX11000C1002XX A* Add-on therapy for intractable partial epilepsy ADULT: Initially 25-50mg nightly for 1 week. Subsequently at wkly or bi-wkly intervals, increase dose by 25-50 to 100mg/day in 2 divided doses. CHILD aged 2 and above: Approx 5-9 mg/kg/day in 2 divided doses. Titrate at 25mg (or less, based on a range of 1-3mg/kg/day) nightly for the 1st week. Subsequently at 1 or 2 wkly intervals, with increments of 1-3 mg/kg/day in 2 divided dose.
1546 Topiramate 25 mg Tablet N03AX11-000-T10-01-XXX A* As adjunctive therapy for adults and children (2 years and above) with: i) partial onset seizures and generalized tonic-clonic seizures ii) seizures associated with Lennox Gastaut syndrome. ADULT: Usual daily dose: 200-400 mg/day. CHILD: Daily doses up to 30mg/kg/day Dosing is according to product insert.
1547 Topiramate 50 mg Tablet N03AX11-000-T10-02-XXX A* As adjunctive therapy for adults and children (2 years and above) with: i) partial onset seizures and generalized tonic-clonic seizures ii) seizures associated with Lennox Gastaut syndrome. ADULT: Usual daily dose: 200-400 mg/day. CHILD: Daily doses up to 30mg/kg/day Dosing is according to product insert.
1548 Trace Elements and Electrolytes (Adult) Solution B05XA30905P3001XX A* Only to be used to cover daily loss of electrolyte and trace elements for patient on parenteral nutrition 10 ml added to 500-1000 ml solution, given by IV infusion
1549 Trace Elements and Electrolytes (Paediatric) Solution B05XA30905P3002XX A* Only to be used to cover daily loss of electrolyte and trace elements for patient on parenteral nutrition According to the needs of the patient. INFANT and CHILD weighing 15 kg or less: Basal requirements of the included trace elements are covered by 1 ml/kg/day to a maximum dose of 15 ml. CHILD weighing 15 kg or more, a daily dose of 15 ml, should meet basic trace element requirements. However, for patients weighing more than 40 kg the adult preparation trace element should be used
1550 Tramadol HCl 50 mg Capsule N02AX02110C1001XX A/KK Moderate to severe acute or chronic pain (eg. Post-operative pain, chronic cancer pain and analgesia/pain relief for patients with impaired renal function) ADULT: 50mg initially, can take another 50mg after 30 - 60 min if pain not relieved. Max 400 mg daily. CHILD: 1mg/kg/dose repeated every 6 hours (Max: 2mg/kg/dose and 100mg/dose)
1551 Tramadol HCl 50 mg/ml Injection N02AX02110P3001XX A Moderate to severe acute or chronic pain (eg. Post-operative pain, chronic cancer pain and analgesia/pain relief for patients with impaired renal function) ADULT: IV/IM/SC 50 - 100mg. (IV inj over 2-3 min or IV infusion). Initially 100 mg then 50 - 100 mg every 4 - 6 hours. . Max: 400 mg daily. CHILD (1 year and above): 1 - 2mg/kg/dose
1552 Tranexamic Acid 100 mg/ml Injection B02AA02000P3001XX B Haemorrhage associated with excessive fibrinolysis ADULT: Slow IV 0.5-1 g (10 - 15 mg/kg) 3 times daily. Continuous infusion at a rate of 25 - 50 mg/kg daily. CHILD: slow IV 10 mg/kg/day 2-3 times daily
1553 Tranexamic Acid 250 mg Capsule B02AA02000C1001XX B Haemorrhage associated with excessive fibrinolysis ADULT: 1-1.5 g (15-25 mg/kg) 2-4 times daily. CHILD: 25 mg/kg/day 2-3 times daily. Menorrhagia (initiated when menstruation has started), 1 g 3 times daily for up to 4 days; maximum 4 g daily
1554 Trastuzumab 440 mg Injection L01XC03000P4001XX A* Used only in adjuvant setting for patients with HER2 over-expressed breast cancer, that is HER2 3+ by immunohistochemistry and over-expressed by FISH (Fluorescence in situ hybridization) and high risk group Initial loading dose is 4 mg/kg administered as a 90 minutes IV infusion. Subsequent doses is 2 mg/kg administered as 30 minutes IV infusion weekly for 51 weeks
1555 Trastuzumab 600mg/5ml Solution for Injection (for subcutaneous) L01XC03000P3001XX A* Used only in adjuvant setting for patients with HER2 over-expressed breast cancer, that is HER2 3+ by immunohistochemistry and over-expressed by FISH (Fluorescence in situ hybridization) and high risk group. The recommended fixed dose of trastuzumab 600mg is 600mg irrespective of the patient?s body weight. No loading dose is required. This dose should be administered over 2-5 minutes every three weeks.
1556 Travoprost 0.004% & Timolol 0.5% Eye Drops S01ED51990D2003XX A* To decrease intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to other topical anti glaucomas 1 drop in the affected eye(s) once daily
1557 Tretinoin 0.01% Gel D10AD01000G3001XX A/KK Acne vulgaris, recalcitrant cases of acne (comedonal type) Apply thinly to the affected area once daily or twice daily. Avoid exposure to sunlight. Duration of treatment: 8-12 weeks is required before any noticeable response
1558 Tretinoin 0.05% Cream D10AD01000G1001XX A/KK Acne vulgaris and recalcitrant cases of acne (comedonal type) Apply thinly to the affected area once daily or twice daily. Avoid exposure to sunlight. Duration of treatment: 8 - 12 weeks is required before any noticeable response
1559 Tretinoin 0.1% Cream D10AD01000G1002XX A Acne vulgaris and recalcitrant cases of acne (comedonal type) Apply thinly to the affected area once daily or twice daily. Avoid exposure to sunlight. Duration of treatment: 8 - 12 weeks is required before any noticeable response
1560 Triamcinolone Acetonide 0.1% Oral Paste A01AC01351G3101XX B Oral and perioral lesions Apply a thin layer to affected area 2-4 times daily

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