Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
331 Ciclosporin Ophthalmic Emulsion 0.05% S01XA18000D2001XX A* To increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca. Increased tear production was not seen in patients currently taking anti inflammatory drugs or using punctal plugs. 1 drop twice a day in each eye approximately 12 hours apart.
332 Cilostazol 100 mg Tablet B01AC00000T1002XX A* Improvement of the maximal and pain-free walking distances in patients with intermittent claudication, who do not have rest pain and who do not have evidence of peripheral tissue necrosis. 100 mg twice daily
333 Cimicifuga Racemosa Rhizome Extract 20 mg Tablet HG03WA5001T1001XX A Traditionally used for the relief of hot flushes, sweating, restlessness associated with menopause 20 mg twice daily
334 Cinacalcet Hydrochloride 25mg tablet H05BX01110T1001XX A* Secondary hyperparathyroidism in patients undergoing maintenance dialysis with hypercalcaemia. For treatment of refractory secondary hyperparathyroidism in patients with end-stage renal disease (including those with calciphylaxis) only in those: i) who have 'very uncontrolled' plasma levels of intact parathyroid hormone (defined as greater than 85pmol/L [800 pg/mL] that are refractory to standard therapy, and an adjusted serum calcium level at upper limit of normal or high, despite appropriate adjustment of phosphate binders including non-calcium based phosphate binders. ii) in whom surgical parathyroidectomy is contraindicated in that the risks of surgery are considered to outweigh the benefits, or if there is likely to be a significant delay for surgery. The starting dose for adults is 25mg once daily to be administered orally. Depending on the serum parathyroid hormone (PTH) and calcium levels, the dose may be adjusted within a range of 25-75mg once daily. If no improvement in PTH, the dose may be increased up to 100 mg once daily. Dose can be increased by 25mg at a time at intervals of at least 3 weeks.
335 Cinnarizine 25 mg Tablet N07CA02000T1001XX B Vestibular disorders Adult: One tablet 3 times daily
336 Ciprofloxacin 100 mg/50 ml Injection J01MA02125P3001XX A Treatment of infections due to susceptible bacterial strains ADULT: the dosage range is 100-400mg twice daily Gonorrhoea: 100mg single dose Upper and Lower Urinary Tract Infection: 100mg bd Upper and Lower Respiratory Tract Infection: 200mg bd-400mg twice daily Cystic Fibrosis with psuedomonal Lower RTI: 400mg bd Others: 200-400mg bd inhalation Anthrax: 400mg bd
337 Ciprofloxacin 200 mg/100 ml Injection J01MA02125P3002XX A Treatment of infections due to susceptible bacterial strains Suggest to rephrase ADULT: the dosage range is 100-400mg twice daily Gonorrhoea: 100mg single dose Upper and Lower Urinary Tract Infection: 100mg bd Upper and Lower Respiratory Tract Infection: 200mg bd-400mg twice daily Cystic Fibrosis with psuedomonal Lower RTI: 400mg bd Others: 200-400mg bd inhalation Anthrax: 400mg bd
338 Ciprofloxacin 250 mg Tablet J01MA02110T1001XX A Treatment of infections due to susceptible bacterial strains ADULT: 125-750 mg twice daily. Acute gonorrhoea: a single dose of 250 mg
339 Ciprofloxacin 500 mg Tablet J01MA02110T1002XX A Treatment of infections due to susceptible bacterial strains ADULT: 125-750 mg twice daily. Acute gonorrhoea: a single dose of 250 mg
340 Ciprofloxacin HCl 0.3% Ophthalmic Solution S01AX13110D2001XX A* Treatment of bacterial infections caused by susceptible strains in i) corneal ulcers ii) bacterial conjunctivitis i) 2 drops every 15 minutes for the first 6 hours, then 2 drops every 30 minutes for the rest of the first day. Second day : 2 drops every hour. Subsequent days (3rd - 14th day) : 2 drops every 4 hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occured ii) 1 - 2 drops every 2 hours into the conjunctival sac while awake for 2 days and 1-2 drops every 4 hours while awake for the next 5 days
341 Cisatracurium Besylate 2 mg/ml Injection M03AC11197P3001XX A* As an adjunct to general anaesthesia to facilitate endotracheal intubation, to provide skeletal muscle relaxation during surgery and to facilitate mechanical ventilation. Restricted to patients with lung problem such as asthma. Administered as bolus intravenous injection. May be administered as infusion in ICU patients at a rate of 3mcg/kg/min. Adult dose: a) Induction: 0.15mg/kg over 5-10 secs, b) Maintenance: 0.03 mg/kg. Children 2-12 years: a) Induction: 0.1 mg/kg over 5-10 secs, b) Maintenance: 0.02 mg/kg
342 Cisplatin 1 mg/mL Injection L01XA01000P3001XX A 1) Solid tumours; 2) lymphomas Germ cell tumours: 20 mg/m2 daily for 5 days every 3 weeks for 3 - 4 courses. Ovarian tumours: 75 mg/m2 once every 3 weeks as part of combination therapy with paclitaxel or 50-60mg/m2 IV once every 3 weeks as a single agent. Baseline creatinine clearance, pretreatment hydration and forced diuresis are mandatory. CHILD: 100mg/m2 over 6 hours once every 3 weeks. Lymphomas: Refer to protocols CHILD: 100mg/m2 over 6 hours once every 3 weeks. Lymphomas: Refer to protocols
343 Clarithromycin 125 mg/5 ml Granules J01FA09000F1001XX A* Treatment of complicated respiratory tract infections not responding to standard macrolides CHILD: 8 - 12 years: 30 - 40 kg 10 mL, 4 - 8 years: 20 - 29 kg 7.5 mL, 2 - 4 years: 12 - 19 kg 5 mL, 1 - 2 years: 8 - 11 kg 2.5 mL, less than 8 kg: 7.5 mg/kg. To be given twice daily. Maximum dose: 1g/day
344 Clarithromycin 250 mg Tablet J01FA09000T1001XX A* Only for i) treatment of complicated respiratory tract infection not responding to standard macrolides ii) eradication of Helicobacter pylori infection i) 250 - 500 mg twice daily. Up to 6 - 14 days ii) 500 mg twice daily with omeprazole & amoxicillin. Up to 2 weeks
345 Clarithromycin 500 mg Injection J01FA09000P3001XX A* Only for treatment of complicated respiratory tract infection not responding to standard macrolides Susceptible infections Adult: 500 mg bid for 2-5 days. Dose to be infused over 60 minutes in a 0.2% solution; revert to oral therapy whenever possible. Child: 1 mth-12 yr: 7.5 mg/kg every 12 hr. Dose to be given via infusion into proximal vein. Dosage Recommendation CrCl (ml/min)<30 : Half the dosage or double dosing interval
346 Clindamycin HCl 300 mg Capsule J01FF01110C1001XX A* i) Skin and soft tissue infections, bone& joint infections ii) Cerebral toxoplasmosis iii) Children less than 8 years old:Treatment and prophylaxis of malaria in combination with quinine, as an alternative to doxycline i) ADULT: 150 - 300 mg every 6 hours; up to 450 mg every 6 hours in severe infections; Max: 1.8g/day CHILD: 3 - 6 mg/kg every 6 hours. Children weighing <10 kg should receive at least 37.5 mg every 8 hr. ii) 600 mg 6 hourly for 6 weeks iii) 10mg/kg twice a day, in combination with quinine. The combination to be given for 7 days
347 Clindamycin Phosphate 150 mg/ml Injection J01FF01162P3001XX A* i) Skin and soft tissue infections, bone & joint infections ii) Cerebral toxoplasmosis i) ADULT: 0.6 - 2.7 g daily (in 2 - 4 divided doses); up to 4.8 g daily; CHILD over 1 month, 20 - 40 mg/kg/day or 350 mg/m2/day in 3 - 4 divided doses ii) 1200 mg every 6 hours for 3 weeks followed by 300 mg orally every 6 hours for another 3 weeks
348 Clobazam 10 mg tablet N05BA09000T1001XX A* As adjunctive therapy in patients with epilepsy not adequately stabilised with their basic medication. The initial dose in adults and adolescents >15 yr should be low (5 to15mg daily), if necessary, increased gradually to a maximum daily dose of about 80mg. Doses of up to 30mg may be taken as a single dose in the evening. The initial dose in children from 3 to15 yr is normally 5mg. A maintenance dose of 0.3 to 1.0mg/kg body weight daily is usually sufficient.
349 Clobetasol Propionate 0.05% Cream D07AD01133G1001XX A Short term treatment only of more resistant dermatoses eg. psoriasis, recalcitrant eczemas, lichen planus, discoid lupus erythematosus and other conditions which do not respond satisfactorily to less potent steroids Apply sparingly once or twice daily, changing to lower potency therapy as soon as condition is controlled. For mild to moderate use maximum for 2 weeks. For moderate to severe maximum duration 4 consecutive weeks. Max: 50 g/week
350 Clobetasol Propionate 0.05% Ointment D07AD01133G5001XX A Short term treatment only of more resistant dermatoses eg. psoriasis, recalcitrant eczemas, lichen planus, discoid lupus erythematosus and other conditions which do not respond satisfactorily to less potent steroids Apply sparingly once or twice daily, changing to lower potency therapy as soon as condition is controlled. For mild to moderate use maximum for 2 weeks. For moderate to severe maximum duration 4 consecutive weeks. Max:50 g/week
351 Clobetasone Butyrate 0.05% Cream D07AB01255G1001XX A/KK Eczema and dermatitis of all types Apply up to four times daily until condition improves, then reduce frequency
352 Clobetasone Butyrate 0.05% Ointment D07AB01255G5001XX A Eczema and dermatitis of all types Apply up to four times daily until condition improves, then reduce frequency
353 Clodronate 800 mg Tablet M05BA02011T1011XX A* Treatment of hypercalcaemia due to malignancy 2 tablets in single or two divided doses
354 Clofazimine 100 mg Capsule J04BA01000C1002XX B i) Previously untreated leprosy patients ii) Leprosy patients resistant to sulphones iii) Suppression of lepra reactions i) ADULT: 100 mg each other day or 50 mg daily with 100mg Dapsone & 300mg once a month with 600mg rifampicin under supervision. Maximum: 200 mg/day. CHILD: 10-14 yr: 50mg clofazimine on alternate days with 50mg dapsone & 150 mg clofazimine with 450 mg rifampicin once a month.Maximum: 100 mg/day. ii) 100 mg daily iii) 200-300mg usually effective. Treatment with minimum suppression dose continued for at least 6 months
355 Clofazimine 50 mg Capsule J04BA01000C1001XX B i) Previously untreated leprosy patients ii) Leprosy patients resistant to sulphones iii) Suppression of lepra reactions i) ADULT: 100 mg each other day or 50 mg daily with 100mg Dapsone & 300mg once a month with 600mg rifampicin under supervision. Maximum: 200 mg/day. CHILD: 10-14 yr: 50mg clofazimine on alternate days with 50mg dapsone & 150 mg clofazimine with 450 mg rifampicin once a month.Maximum: 100 mg/day. ii) 100 mg daily iii) 200-300mg usually effective. Treatment with minimum suppression dose continued for at least 6 months
356 Clomiphene Citrate 50mg Tablet G03GB02136T1001XX A Anovulatory infertility 50 mg daily from 2nd - 6th or 5th - 9th day of menstrual cycle. Increase dose gradually by increments of 50 mg if there is no response until a dosage of 200 mg daily is achieved (starting as early as 30 days afer the previous course). Further treatment may not be recommended if pregnancy has not occurred after a total of 6 treatment cycles.
357 Clomipramine HCI 25 mg Tablet N06AA04110T1001XX A Depression, obsessive-compulsive disorder. Initially 10 mg daily, increased gradually as necessary to 30 - 150 mg daily in divided doses or as a single dose at bedtime; max 250 mg daily. ELDERLY initially 10 mg daily increased carefully over approximately 10 days to 30 - 75 mg daily;Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.
358 Clonazepam 0.5 mg Tablet N03AE01000T1001XX B i) Epilepsy ii) Non-epileptic myoclonus i) & ii) ADULT: Initial dose should not exceed 1.5mg/day divided into 3 doses, may be increased in increments of 0.5mg every 3 days until seizures are controlled. Maintenance dose: 3-6mg/day. Maximum: 20mg/day. CHILD up to 10 years: initial dose 0.01-0.03 mg/kg/day in 2-3 divided doses, increased by no more than 0.25-0.5mg every third day, maximum 0.2mg/kg/day. CHILD 10-16 years: initial dose 1-1.5mg/day in 2-3 divided dose, may be increased by 0.25-0.5mg every third day until individual maintenance dose of 3-6mg/day is reached.
359 Clonazepam 2 mg Tablet N03AE01000T1002XX B i) Epilepsy ii) Non-epileptic myoclonus i) & ii) ADULT: Initial dose should not exceed 1.5mg/day divided into 3 doses, may be increased in increments of 0.5mg every 3 days until seizures are controlled. Maintenance dose: 3-6mg/day. Maximum: 20mg/day. CHILD up to 10 years: initial dose 0.01-0.03 mg/kg/day in 2-3 divided doses, increased by no more than 0.25-0.5mg every third day, maximum 0.2mg/kg/day. CHILD 10-16 years: initial dose 1-1.5mg/day in 2-3 divided dose, may be increased by 0.25-0.5mg every third day until individual maintenance dose of 3-6mg/day is reached.
360 Clonidine HCl 0.025 mg Tablet N02CX02110T1001XX A Rapid opiod detoxification combination use with naltrexone Rapid detoxification in 4-5 days (use with naltrexone): 6 mcg/kg ORALLY divided in 3 doses 6 to 8 hours apart the first day, increasing to 11 mcg/kg divided in 3 doses given day two, tapering to 0.6 mcg/kg the third day. Rapid opioid detoxification for 7 days ( use with naltrexone) : 0.1 to 0.2 mg every 4 hours as needed

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